Pareto's principle states that 80% of results come from 20% of effort. You can apply that to business, relationships, jobs, just about everything in life and eBay is no difference. Pareto's principle, as it applies to business suggests that you should focus the bulk of your marketing efforts on the most profitable 20% of your customers. If you were an eBay seller that sold a large amount of items in the same niche frequently, you may be able to benefit from this strategy.
How To Get A List Of Your Buyers
Getting a list of your buyers for a period of time can be easy if you are using good auction management software. eBay's own Selling Manager Pro allows you to download all your customers as a .CSV file which contains their email addresses, eBay username and total price they paid for items.

This is a screenshot from Marketplace Advisor, which has a reporting tool that enables you to download all your sales for a specified period of time and includes the same information as eBay's Selling Manager Pro report does.
How To Find The Most Profitable 20%




Now you should look these customers up in your records or auction management software to see their ordering history.
What To Do With The Most Profitable 20%
Now that you know which of your customers buy the most, you should look them up in your records or auction management software to see their ordering history. Look at the individual products they bought and see if you can find a common theme. Maybe they buy a certain size, color, artist or genre from you. See if you can get to know their taste so that when you get a new product that is similar to what they have bought before, you can email them personally and let them know about the new product. Of course, if you could find a way to automate it Amazon-style, that would be even better and I would love to hear about it.
Also consider creating a special email filter for these people so that whenever they email you with a problem of question, you make sure to pay extra attention to them. If you review your top 20% every month, you'll find that adjusting your VIP customer marketing email filter only takes a few minutes because you are only changing a handful of names.